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03315.txt
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1994-01-17
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$Unique_ID{BRK03315}
$Pretitle{}
$Title{pseudoephedrine and azatadine combination}
$Subject{Trinalin Repetabs Schering Adrenergic decongestant antihistamine
pseudoephedrine azatadine upper respiratory tract infections hay fever
allergies sinusitis inflammation sinuses constricting narrowing blood vessels
nasal passages swelling congestion histamine chemical allergic reaction
allergy}
$Volume{}
$Log{
Trinalin Repetabs*0331501.scf}
Copyright (C) 1993 Publications International, Ltd.
pseudoephedrine and azatadine combination
------------------------------------------------------------------------------
BRAND NAME (Manufacturer)
Trinalin Repetabs (Schering)
TYPE OF DRUG
Adrenergic (decongestant) and antihistamine
INGREDIENTS
pseudoephedrine and azatadine
DOSAGE FORM
Sustained-release tablets (120 mg pseudoephedrine and 1 mg azatadine)
STORAGE
Pseudoephedrine and azatadine combination tablets should be stored at
room temperature in a tightly closed container.
USES
Pseudoephedrine and azatadine combination medication is used to relieve
the symptoms of upper respiratory tract infections, hay fever and other
allergies, and sinusitis (inflammation of the sinuses).
Pseudoephedrine belongs to a group of drugs known as adrenergic agents
(decongestants). They act by constricting (narrowing) blood vessels in the
nasal passages to reduce swelling and congestion.
Azatadine belongs to a group of drugs known as antihistamines, which
block the action of histamine, a chemical released by the body during an
allergic reaction. It is, therefore, used to relieve or prevent symptoms of
allergy.
TREATMENT
In order to avoid stomach upset, you can take pseudoephedrine and
azatadine combination with food or with a full glass of milk or water unless
otherwise directed.
The sustained-release tablets should be swallowed whole. Breaking,
chewing, or crushing these tablets destroys their sustained-release activity
and may increase the side effects.
If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for your next dose. In that case, do not
take the missed dose at all; just return to your regular dosing schedule. Do
not double the next dose.
SIDE EFFECTS
Minor.
Anxiety; blurred vision; constipation; diarrhea; dizziness; drowsiness;
dry mouth, nose, and throat; heartburn; insomnia; irritability; loss of
appetite; nasal congestion; nausea; restlessness; decreased sweating;
vomiting; or weakness. These side effects should disappear as your body
adjusts to the medication.
This medication can increase your sensitivity to sunlight. Avoid
prolonged exposure to sunlight and sunlamps.
If you are constipated, increase the amount of fiber in your diet (fresh
fruits and vegetables, salads, bran, and whole-grain breads), exercise, and
drink more water (unless your doctor directs you to do otherwise).
Chew sugarless gum or suck on ice chips or a piece of hard candy to
reduce mouth dryness.
If you feel dizzy or light-headed, sit or lie down for a while; get up
slowly from a sitting or reclining position, and be careful on stairs.
In order to avoid difficulty in falling asleep, take this medication
several hours before bedtime.
Major.
Tell your doctor about any side effects that are persistent or
particularly bothersome. TELL YOUR DOCTOR about chest pain, confusion,
convulsions, difficult or painful urination, difficulty in breathing,
fainting, hallucinations, headaches, loss of coordination, mood changes,
nosebleeds, palpitations, rash, severe abdominal pain, sore throat, or unusual
bleeding or bruising.
INTERACTIONS
Pseudoephedrine and azatadine combination can interact with several other
types of medications:
1. Concurrent use of this medication with central nervous system
depressants (drugs that slow the activity of the brain and spinal cord), such
as alcohol, barbiturates, benzodiazepine tranquilizers, muscle relaxants,
narcotics, pain medications, and phenothiazine tranquilizers, or with
tricyclic antidepressants can cause extreme drowsiness.
2. Monoamine oxidase (MAO) inhibitors (isocarboxazid, pargyline,
phenelzine, or tranylcypromine) and tricyclic antidepressants can increase the
side effects of this drug. At least 14 days should separate the use of this
drug and the use of an MAO inhibitor.
3. The action of oral anticoagulants (blood thinners) may be decreased by
the antihistamine component of this drug.
4. Procarbazine may interact with the antihistamine component of this
drug.
5. The side effects of the antihistamine component of this medication may
be increased by quinidine, procainamide, haloperidol, and phenothiazine
tranquilizers.
6. The side effects of the decongestant component of this drug may be
increased by digoxin or over-the-counter asthma, allergy, cough, cold, diet,
or sinus preparations.
7. The blood-pressure-lowering effects of guanethidine may be decreased
by this medication.
TELL YOUR DOCTOR about any medications you are currently taking.
WARNINGS
* Tell your doctor about unusual or allergic reactions you have had to
any medications, especially to azatadine or other antihistamines (such as
brompheniramine, carbinoxamine, chlorpheniramine, clemastine, cyproheptadine,
dexchlorpheniramine, dimenhydrinate, dimethindene, diphenhydramine,
diphenylpyraline, doxylamine, hydroxyzine, promethazine, pyrilamine,
trimeprazine, tripelennamine, and triprolidine) or to pseudoephedrine or other
adrenergic agents (such as albuterol, amphetamines, ephedrine, epinephrine,
isoproterenol, metaproterenol, norepinephrine, phenylpropanolamine, and
terbutaline).
* Be sure to tell your doctor if you now have or if you have ever had
diabetes mellitus, epilepsy, glaucoma, heart or blood vessel disease, hiatal
hernia, high blood pressure, myasthenia gravis, obstructed bladder or
intestinal tract, peptic ulcers, enlarged prostate gland, or thyroid disease.
* This drug can reduce sweating and heat release from the body. Be sure
to avoid excessive work and exercise in hot weather, and do not take hot
baths, showers, and saunas.
* This medication can cause drowsiness. Your ability to perform tasks
that require alertness, such as driving a car or operating potentially
dangerous machinery, may be decreased. Appropriate caution should, therefore,
be taken.
* Be sure to tell your doctor if you are pregnant. The effects of this
medication during pregnancy have not been thoroughly studied in humans. Also,
be sure to tell your doctor if you are currently breast-feeding an infant.
Small amounts of this medication pass into breast milk and may cause unusual
excitement or irritability in nursing infants.
----------------
The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician. Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.